New DNA Nanoprobe Lights Up Oral Tumors to Guide Surgery in Mice
Researchers developed a target-responsive tetrahedral DNA nanoprobe that switches on fluorescence when it detects tumor-associated nucleolin or microRNA-21. In cell and mouse experiments, the probe enabled tumor imaging and fluorescence-guided surgery, although its safety, accuracy, and clinical value still require further testing.
A switchable DNA structure designed to stay dark until it encounters tumor-associated targets could give surgeons a clearer view of hard-to-reach oral and maxillofacial tumors. Paper: Fabrication of dynamic tetrahedral DNA structure probe for precisi... [8120 chars]
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