Effects of clinically available HIF-PH inhibitors on retinal Vegfa transcription
Hypoxia-inducible factor (HIF) plays a central role in the cellular response to hypoxia and is negatively regulated under normoxic conditions by prolyl hydroxylase domain-containing proteins (PHDs), also referred to as HIF prolyl hydroxylases (HIF-PHs). HIF-PH inhibitors induce erythropoietin (EPO) expression by activating HIF and are widely used for the treatment of renal anemia; however, their effects on intraocular vascular endothelial growth factor (VEGF) expression remain unclear. In this study, we examined the effects of all five HIF-PH inhibitors (roxadustat, daprodustat, vadadustat…
Chronic kidney disease (CKD) affects an estimated 800 million individuals worldwide and is frequently accompanied by renal anemia, one of the major complications of the disease1. In CKD, impaired renal function leads to reduced erythropoietin (EPO) p... [19706 chars]
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